Levitate is a spin-out of Cyrus Biotechnology. Cyrus, initially established as a spin-out of the Baker Lab where Rosetta originated, was dedicated to developing Bench, an intuitive online version of Rosetta. While Bench development was halted in 2019 to prioritize protein therapeutics advancement, Cyrus continued to refine Rosetta and AI protocols internally via APIs to help model their therapeutics. In 2024, Cyrus underwent a restructuring, resulting in two distinct entities: one focused on therapeutics development under the Cyrus banner and the other, Levitate Bio, solely managing software, services, and IT operations. Levitate Bio’s inaugural client became Cyrus, subscribing to software access and utilizing Levitate’s IT services.
Our Protocols
De Novo Design
- RosettaFold Diffusion
- Hallucinate novel structures from scratch to create new folds, binders, and linkers that are highly stable.
- ProteinMPNN
- Hallucinate novel sequences that are favorable for your protein structure and highly stable.
Mutation Sampling & Design
- Rosetta Design
- Redesign target regions with physics-based sampling of combinations of mutations
- Disulfidizer
- Scan structure for favorable disulfide
- Point Mutation Scan
- RosettaDDG or ThermoMPNN (AI)
Protein Structure Prediction
- Homology Modeling
- Template-based modeling with Rosetta optimization
- Artificial Intelligence
- AlphaFold2, OpenFold, ESMFold, and AlphaFold2 Multimer
Protein Structure Optimization
- Relax, Prepare, Loop Model, Minimize, or Repack
- Rosetta’s physics-based tools optimize full structures, loops, or side-chains
Analysis of Structure and/or Sequence
- Liability Prediction
- Epitope Scan
- Solubility Prediction
- Degradation Prediction
- Glycosylation
- Model Analysis
- RosettaHoles
- Radius of Gyration
- Interface Analysis
Our Team
Sam DeLuca, PhD
CEO
Karen Khar, PhD
Executive Vice President of Sales and Business Development
Brandon Frenz, PhD
Director of Scientific Software
Toni Stamper
Director of Business Operations
Joe Ylagan
Senior Site Reliability Engineer
Aaron Aguhob
Scientific Software Engineer
Ben Baker
Senior Software Engineer
Thomas Tuong
Site Reliability Engineer