Levitate is a spin-out of Cyrus Biotechnology. Cyrus, initially established as a spin-out of the Baker Lab where Rosetta originated, was dedicated to developing Bench, an intuitive online version of Rosetta. While Bench development was halted in 2019 to prioritize protein therapeutics advancement, Cyrus continued to refine Rosetta and AI protocols internally via APIs to help model their therapeutics. In 2024, Cyrus underwent a restructuring, resulting in two distinct entities: one focused on therapeutics development under the Cyrus banner and the other, Levitate Bio, solely managing software, services, and IT operations. Levitate Bio’s inaugural client became Cyrus, subscribing to software access and utilizing Levitate’s IT services.

As a Levitate customer, our team of expert protein engineers will work closely with you starting from the initial exploratory call to make sure that we understand the problems you’re trying to solve and ensure that we can provide you with the tools you need. Our experience in this industry has shown us that every project has different requirements, and we foster collaborative relationships with you by developing new features or even new tools to solve your problems. This may include utilization of existing tools but can also include the development of new features or even entirely new tools as the situation requires. Thanks to our many close relationships with cutting edge protein engineering labs we can also provide unique insight into tools currently under development that may be applicable to your use case.

To help you get the most out of Levitate’s products from day one of your trial, we offer 3 hours of complimentary live training as part of our onboarding process. This training is tailored to the needs and experience of your team. Our team of scientists and engineers with years of experience working on commercial drug discovery programs are ready to help. We’ll work closely with you via email, Slack, or Zoom to address any technical or scientific issues you run into. Regardless of how closely we work with you as a customer, one thing never changes: your intellectual property remains entirely your own.

We take protection of your intellectual property seriously, and will work with your information security and IT teams to meet your security and operational requirements. By default we host our applications within our own managed Google Cloud environment, but we can also deploy to any cloud provider or even your own on premise infrastructure.

Collaboration is key to success in any scientific endeavour, and we believe that making our experience in protein engineering and computational biology available to all our customers results in far better outcomes than simply making the tools available without support. Simply put, we succeed when you succeed.

Our Protocols

De Novo Design

RosettaFold Diffusion
- Hallucinate novel structures from scratch to create new folds, binders, and linkers that are highly stable.
ProteinMPNN
- Hallucinate novel sequences that are favorable for your protein structure and highly stable.

Mutation Sampling & Design

Rosetta Design
- Redesign target regions with physics-based sampling of combinations of mutations
Disulfidizer
- Scan structure for favorable disulfide
Point Mutation Scan
- RosettaDDG or ThermoMPNN (AI)

Protein Structure Prediction

Homology Modeling
- Template-based modeling with Rosetta optimization
Artificial Intelligence
- AlphaFold2, OpenFold, ESMFold, and AlphaFold2 Multimer

Protein Structure Optimization

Relax, Prepare, Loop Model, Minimize, or Repack
- Rosetta’s physics-based tools optimize full structures, loops, or side-chains

Analysis of Structure and/or Sequence

Liability Prediction
- Epitope Scan
- Solubility Prediction
- Degradation Prediction
- Glycosylation
Model Analysis
- RosettaHoles
- Radius of Gyration
Interface Analysis